Vous êtes ici : Version française > Parcours du doctorant > Formation

Colloque / Séminaire

Deux séminaires LaMCoS (présentiel - INSA) : "High Frequency Ultrasound of Mobile Microrobots for Biomedical Applications" et "Enhancing MRI measurements of cerebral flow using principles of flow dynamics"

Le 12 juin 2023

14h
Salle Bellecour (bât. Sophie Germain, INSA)

Langue / language: the presentation will be in English

Présentés par : Craig J. GOERGEN, Ph.D., Weldon School of Biomedical Engineering Purdue University, West Lafayette, Indiana et Vitaliy L. RAYZ, Ph.D., Weldon School of Biomedical Engineering Purdue University, West Lafayette, Indiana

Résumés et biographies des orateurs

Craig J. GOERGEN, Ph.D., Weldon School of Biomedical Engineering Purdue University, West Lafayette, Indiana


"High Frequency Ultrasound of Mobile Microrobots for Biomedical Applications"

Résumé :
Mobile microrobots have many vast potential medical applications, such as targeted drug delivery, biopsy, hyperthermia, brachytherapy, scaffolding, in vivo ablation, sensing, marking, and stem cell therapy. They can revolutionize existing therapies by allowing for disease monitoring, highly localized drug delivery, minimally invasive surgery, and stem cell therapy to be performed inside the human body. The application of mobile microrobots in these biomedical applications requires a truly multidisciplinary investigation in the areas of microrobot design, fabrication, locomotion modes, actuation and control systems, and realtime visualization. In this presentation, we describe efforts for the development of various types of magnetic mobile microrobots for in vivo biomedical applications. This collaborative work has led to the development of novel magnetic micro-scale tumbling microrobots (μTUM) that can traverse complex surfaces in both wet and dry environments along with
real-time ultrasound imaging of the microrobots locomoting in various animal models.


et

Vitaliy L. Rayz, Ph.D., Weldon School of Biomedical Engineering Purdue University, West Lafayette, Indiana

"Enhancing MRI measurements of cerebral flow using principles of flow dynamics"

Résumé :
The flow dynamics of neurofluids – blood and cerebrospinal fluid (CSF) – plays an important role in brain health and function. Abnormal blood flow is a hallmark of cerebrovascular diseases such as intracranial atherosclerotic disease or aneurysms. Impaired CSF flow and transport are implicated in neurodegenerative and neurodevelopmental diseases/disorders. Reliable quantification of relevant flow metrics can provide valuable data for predicting neurovascular/neurodegenerative disease progression or for treatment planning. Computational fluid dynamics (CFD) models can provide high-resolution velocity fields, but their reliability depends on modeling assumptions. Alternatively, flow velocities can be measured in vivo with three-directional phase-contrast MRI (4D Flow MRI), however its accuracy is affected by limited by resolution and image noise. In this talk we will discuss the limitations of the current imaging and modeling approaches for subject-specific analysis of cerebral flow dynamics and present 4D flow error augmentation approach where principles of fluid dynamics are used to estimate and reduce the error of MRI measurements.